What is the M365 Pill?
Medically Reviewed By: Dr. Joshua Yager M.D.
Dr. Joshua Yager is an Atlanta native and a board-certified family practice physician committed to the health and well-being of his community.
Table of Contents
- What Is the M365 Pill?
- Side Effects of the M365 Pill
- Medications Similar to the M365 Pill
- Is the M365 Pill Addictive?
- Common Uses of M365 Pills
- Signs That Someone is Using M365 Pills
- How Does the M365 Pill Interact with Your Body?
- How Long Does the M365 Pill Stay in Your System?
- M365 Pill Addiction
- M365 Overdose
- M365 Pill Interactions with Alcohol & Other Substances
- Treatment for M365 Pill Addiction in Atlanta, GA
What Is the M365 Pill?

The M365 pill is a prescription medication commonly used to relieve moderate to severe pain. It contains two active ingredients:
- Hydrocodone: An opioid analgesic that alters how the brain and nervous system respond to pain signals.
- Acetaminophen: A non-opioid pain reliever commonly found in over-the-counter medications like Tylenol.
Hydrocodone, like other opioids, carries a risk of tolerance, physical dependence, and addiction. Understanding its effects and risks can help individuals make informed decisions regarding pain management and overall health.
Side Effects of the M365 Pill
M365, which contains acetaminophen and hydrocodone bitartrate, can cause common side effects similar to other pain medications. While generally safe at prescribed doses, discussing potential risks with a healthcare provider is essential before use.
The medication may impair motor skills and cause dizziness, leading doctors to advise against driving or operating heavy machinery while taking it. Common side effects include:
- Lightheadedness
- Nausea
- Vomiting
- Constipation
- Drowsiness
More severe side effects requiring immediate medical attention include:
- Swelling of the face, mouth, or throat (allergic reaction)
- Development of drug dependence and withdrawal symptoms
- Liver damage or failure
- Breathing difficulties
- Changes in appetite
Medications Similar to the M365 Pill
Norco
Norco is a brand-name opioid medication manufactured by Watson Pharmaceuticals, available in different strengths:
- Acetaminophen (325mg) + Hydrocodone (5mg)
- Acetaminophen (325mg) + Hydrocodone (7.5mg)
- Acetaminophen (325mg) + Hydrocodone (10mg)
The first formulation matches the M365 pill in composition. Hydrocodone, a semi-synthetic opioid, is a key contributor to the opioid crisis in the U.S.
Vicodin
Vicodin, manufactured by Abbott Pharmaceuticals, is another opioid analgesic available in:
- Acetaminophen (300mg) + Hydrocodone (5mg)
- Acetaminophen (300mg) + Hydrocodone (7.5mg)
- Acetaminophen (300mg) + Hydrocodone (10mg)
The primary difference between Norco and Vicodin lies in acetaminophen content—Norco contains 325mg, while Vicodin has 300mg.
Is the M365 Pill Addictive?

Yes, the M365 pill has a high potential for addiction due to its hydrocodone content. According to the National Institute on Drug Abuse (NIDA), hydrocodone is one of the most commonly prescribed and abused opioids in the U.S.
Many individuals start taking M365 as prescribed but may develop dependence if used long-term. Dependence can lead to addiction, especially for those who misuse the medication for its euphoric effects.
Common Uses of M365 Pills
Doctors prescribe M365 for various pain conditions, including:
- Injury-related pain: Alleviates discomfort from fractures or deep lacerations.
- Post-surgical pain: Helps in recovery following surgical procedures.
- Chronic pain: Manages conditions like arthritis and severe back pain.
- Dental pain: Reduces pain from major dental procedures like root canals.
Following a doctor’s instructions minimizes the risk of side effects and dependence.
Signs That Someone is Using M365 Pills
Opioid use can lead to dependence and addiction. If you suspect someone is misusing M365, look for these signs:
- Constricted (pinpoint) pupils
- Skin itching or rashes
- Flushed or warm skin
- Dry mouth
- Digestive issues (diarrhea, stomach upset)
- Social withdrawal
- Work or school performance decline
- Sexual dysfunction (in men)
- Nausea, vomiting
- Slurred speech
- Drowsiness or lethargy
How Does the M365 Pill Interact with Your Body?
The combination of hydrocodone and acetaminophen in M365 works to relieve pain effectively.
- Hydrocodone binds to opioid receptors in the brain and spinal cord, altering pain perception.
- Acetaminophen reduces pain by inhibiting certain chemicals in the brain, enhancing the effects of hydrocodone and reducing fever.
M365 helps improve mobility, supports healing, and enhances sleep quality by alleviating pain.
How Long Does the M365 Pill Stay in Your System?
While its pain-relieving effects last a few hours, M365 remains in the body longer:

- Blood: Up to 24 hours
- Urine: 2 to 4 days
- Saliva: 1 to 4 days
- Hair: Up to 90 days
Metabolism, dosage, and individual factors affect how long it stays in your system. Following prescribed guidelines ensures safe use.
The M365 pill is an effective pain reliever but comes with risks, including dependence and addiction. Understanding its uses, side effects, and alternatives can help individuals manage pain safely. Always consult a healthcare provider before starting or stopping this medication.
Here’s an FAQ section addressing the common queries related to the M365 pill:
Frequently Asked Questions (FAQ) About M365 Pill
1. What pill is M365?
The M365 pill is a combination of hydrocodone bitartrate (5 mg) and acetaminophen (325 mg), commonly prescribed for moderate to severe pain relief.
2. Do M365 pills make you sleepy?
Yes, M365 pills can cause drowsiness as hydrocodone is an opioid that affects the central nervous system.
3. What does M365 do?
The M365 pill helps relieve pain by binding to opioid receptors in the brain while acetaminophen reduces fever and enhances pain relief.
4. Is hydrocodone a strong painkiller?
Yes, hydrocodone is considered a potent opioid pain reliever, though it is not the strongest available.
5. What is the strongest painkiller?
Fentanyl is one of the strongest painkillers, followed by morphine and oxycodone.
6. Is hydrocodone the same as Percocet?
No, Percocet contains oxycodone and acetaminophen, while hydrocodone is a different opioid.
7. Is morphine an opioid?
Yes, morphine is a strong opioid used to treat severe pain.
8. How strong are Percocets?
Percocets contain oxycodone, which is stronger than hydrocodone. Their strength depends on the prescribed dosage.
9. Is hydrocodone the same as Vicodin?
Vicodin is a brand name for a combination of hydrocodone and acetaminophen, similar to M365.
10. What does a 7.5 mg hydrocodone look like?
Hydrocodone 7.5 mg pills vary by manufacturer but often have imprints such as M367 or IP 110.
11. Is hydrocodone the same as codeine?
No, hydrocodone is a stronger opioid than codeine, though both are used for pain relief.
12. Is Norco the same as hydrocodone?
Yes, Norco is a brand name for hydrocodone and acetaminophen, similar to M365.
13. What’s the difference between M365 and M367?
M365 contains 5 mg of hydrocodone, while M367 contains 10 mg, making it a stronger version.
14. Is M365 the same as Norco?
Yes, M365 is a generic version of Norco 5/325.
15. Does hydrocodone M365 make you sleepy?
Yes, drowsiness is a common side effect of hydrocodone.
16. Is Norco the same as Percocet?
No, Norco contains hydrocodone, while Percocet contains oxycodone.
17. What are the street names for codeine?
Common street names for codeine include Lean, Purple Drank, and Sizzurp.
18. Is Norco stronger than Vicodin?
Norco and Vicodin are similar, but Norco has a higher ratio of hydrocodone to acetaminophen.
19. What is the new name for Norco?
Norco remains its primary name, but generic versions exist.
20. Is Vicodin stronger than Percocet?
No, Percocet (oxycodone) is generally stronger than Vicodin (hydrocodone).
21. Which is stronger, Lortab or Norco?
Both contain hydrocodone, but Norco often has a lower acetaminophen content.
22. Which is stronger, oxycodone or Norco?
Oxycodone is stronger than hydrocodone in equivalent doses.
23. Is Percocet the same as oxycodone?
Percocet contains oxycodone and acetaminophen, while oxycodone can be prescribed alone.
24. Which is stronger, oxycodone or hydrocodone?
Oxycodone is more potent than hydrocodone.
25. Is oxycodone the same as Percocet?
Percocet contains oxycodone and acetaminophen, while oxycodone can be prescribed alone.
26. Is hydrocodone 7.5 mg strong?
It is a moderate dose, stronger than 5 mg but weaker than 10 mg hydrocodone.
27. What makes you more sleepy, oxycodone or hydrocodone?
Oxycodone can cause more sedation than hydrocodone.
28. Is 10 mg hydrocodone a lot?
It is a high dose commonly prescribed for severe pain.
29. Is hydrocodone as strong as morphine?
Morphine is generally stronger than hydrocodone.
30. Is oxy stronger than morphine?
Oxycodone is comparable in strength to morphine but varies based on dosage and formulation.
31. What kind of narcotic is in hydrocodone?
Hydrocodone is a semi-synthetic opioid narcotic.
32. Which is stronger, hydrocodone or tramadol?
Hydrocodone is stronger than tramadol.
33. What pain pill is stronger than oxycodone?
Fentanyl and hydromorphone are stronger than oxycodone.
34. What is the difference between M365 and M367 pills?
M365 contains 5 mg hydrocodone, while M367 contains 10 mg.
35. Is M367 a Percocet?
No, M367 is a hydrocodone pill, while Percocet contains oxycodone.
36. Why was Vicodin discontinued?
Vicodin was reformulated due to concerns over high acetaminophen levels causing liver damage.
37. What strength is M367 hydrocodone?
M367 contains 10 mg hydrocodone and 325 mg acetaminophen.
38. Is there codeine in hydrocodone?
No, hydrocodone and codeine are different opioids.
39. How often can you take hydrocodone M365?
Typically, it is taken every 4-6 hours as needed for pain, but only as prescribed by a doctor.
40. What is the stronger version of hydrocodone?
Hydrocodone 10 mg formulations (e.g., Norco 10/325) are stronger than M365.
41. What does an M367 pill look like?
M367 is a white, capsule-shaped pill with “M367” imprinted on one side.
42. What is an M365 pill?
M365 is a white, oval pill containing 5 mg hydrocodone and 325 mg acetaminophen, used for pain relief.
43. What is the difference between M367 and M365?
M367 contains 10 mg of hydrocodone, while M365 contains 5 mg.
44. What does M365 stand for?
M365 is the imprint code on a generic hydrocodone-acetaminophen pill.